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Richter transformation remains an ominous event for patients with CLL, especially when it truly is clonally connected to the original CLL, since none of the not long ago accredited novel brokers is really effective. In fact, illness transformation is a comparatively typical explanation for failure to benefit from these medications.ninety,128,129 Histological confirmation is usually suggested because it can manual prognosis (i.e., Hodgkin lymphoma and clonally unrelated tumors have far more favorable prognosis).
Environmental or self-antigens and homotypic interactions induce BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals with the microenvironment and escalating the activation of anti-apoptotic and proliferation pathways.
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